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Still, to pave the way for more widespread clinical applications of gut-based interventions, future research will need to shift emphasis on more reward phases and clinical populations, ideally using larger samples with publication of the associations regardless of their threshold as full maps and regardless of a potential confirmation or rejection of the hypothesized action on reward responses

Shuai Y, Yang G, Zhang Q, Li W, Luo Y, Ma J, et al

GLP-1's caloric restriction causes overnight glucose drops that trigger a cortisol spike (your body's alarm system)

(PubMed) World Cancer Research Fund/American Institute for Cancer Research